Top all-time · #1974
Josh Mitteldorf
Personal blog · joshmitteldorf.scienceblog.comsciencehealth
Josh Mitteldorf writes ScienceBlog.com, a personal blog at joshmitteldorf.scienceblog.com about science and health. Since 2014, 37 different Hacker News readers have linked it 84 times, most often “Age Reduction Breakthrough?”. It is still writing: the last post was on 2026-10-29, and you can follow it by feed.
Too few sampled comments (25) to say how often HN recommends it.?
Why HN links it
Josh Mitteldorf's blog covers aging and longevity research, summarising studies in mice and humans and following life-extension developments. HN commenters link individual posts as overviews or sources.
- Recommended for · 4 comments
- Called good for life-extension updates; a reader should follow its links and read the comments; an interesting post on plasma dilution; a Horvath Clock project
Summarised by Claude from a sample of 25 HN comments that link here. Each comment is marked recommending, critical or neutral (citing without judging); how this works.
Most-linked posts?
- Age Reduction Breakthrough?4 people · 4 mentions · first linked 2020-05-11
- Is Aging Inevitable?3 people · 3 mentions · first linked 2021-06-17
- Politics Influences the Science of Covid-19 – Josh Mitteldorf3 people · 3 mentions · first linked 2020-07-08
- Immune senescence, Christian theology, and the Spike protein2 people · 2 mentions · first linked 2021-12-18
- Universal Clock Implies Universal Clockwork2 people · 2 mentions · first linked 2021-02-05
- Telomerase Therapies in Our Future2 people · 2 mentions · first linked 2015-04-29
- Is aging inevitable?2 people · 2 mentions · first linked 2021-07-10
- Suppression of Chloroquine Is Scandalous2 people · 2 mentions · first linked 2020-06-20
- Out with the Old Blood (Tissue Rejuvenation with Saline-Albumin)2 people · 2 mentions · first linked 2020-06-15
- Is cancer a mitochondrial disease?2 people · 2 mentions · first linked 2017-10-02
What Hacker News says?
Google, when used with double quotes and exact title, finds aggregator sites, but I was simulating looking for the original: https://joshmitteldorf.scienceblog.com/2020/07/08/politics-i... Here is one more, search: Ten Elements of the False COVID Narrative Google: nowhere Brave: first result And it's not like Google just didn't index the site, it works for topics that are "less controversial", search: Universal Cloc…
Comment linking /2020/07/08/politics-influences-the-science-of-covid-19/
on “Brave Search replaces Google as default search engine in the Brave browser”Submitted Age Reduction Breakthrough? as a story · 364 points
HN discussionFrom the paper (DEEX - "Depressed mood and exhaustion"): "Nonetheless, adding DEEX to a risk score based on classical risk factors resulted in only nonsignificant improvement of mortality risk prediction." Regarding the causal relationship: "Although not a proof of causality, in general, depressed subjects are more likely to cluster self-harming lifestyle behaviors and may be less likely to adhere to prescribed medi…
Comment linking /2012/11/10/mortality-and-life-expectancy/
on “Depression as hard on the heart as obesity and cholesterol”Submitted What Is Aging? Most Scientists Still Get It Wrong as a story · 197 points
HN discussionThere's another branch of aging research that is gaining traction recently and that feels just so much more sensible. Its basic idea is that there's really no "wear and tear" happening, but rather, aging is a programmed process whereby cells deliberately disable their various cleaning and healing mechanisms via epigenetic alterations. This whole thing is controlled by signal molecules in the bloodstream, and there's…
Comment linking /2020/05/11/age-reduction-breakthrough/
on “Scientist David Sinclair on why we age and why he thinks we don’t have to (2019)”Submitted Telomeres – Too much of a good thing? as a story · 177 points
HN discussion1. https://old.reddit.com/r/longevity/ 2. https://joshmitteldorf.scienceblog.com (be sure to follow the links to research papers and read the comments) 3. I also made a playlist with videos and lectures on the topic: https://www.youtube.com/playlist?list=PLLvA7pB41pDk27XOjqbXi...
Comment linking /
on “People who live past 105 years old have genes that stop DNA damage”Submitted What Doesn’t Kill Me Makes Me Stronger as a story · 150 points
HN discussion48-72 hours is not long enough to regenerate your immune system. Valter Longo has recommended at least 4-5 days to treat auto-immune disorders [1]. I've done 5 day fasts. For something serious I would try 7. [1] http://joshmitteldorf.scienceblog.com/2014/06/12/the-three-d... “3 days is optimal for mice. For humans 4-5 minimum, depending on what you are trying to achieve”
Comment linking /2014/06/12/the-three-day-fast-day-four/
on “I had an autoimmune disease, then the disease had me (2013)”Submitted The Bredesen protocol for treating Alzheimer’s as a story · 93 points
HN discussionOkay, fair enough. But a major difference is that flu deaths are much more heavily burdened on the the young, whereas Covid is on the very elderly. The death of a 6 month old from flu results in approximately 20 times more QALY loss than an 85 year old. Let me approach it from another angle. Pre-vaccine, it appears that Covid roughly doubled everyone's all-cause mortality.[1] Like it killed 30 year olds at a much lo…
Comment linking /2012/11/10/mortality-and-life-expectancy/
on “The mutation that helps Delta spread”Submitted Is Aging Inevitable? as a story · 80 points
HN discussionAubrey is going grey which would suggest to me if he is practising what he preaches, he's not mastered it yet. Maybe he needs to find out what this cancer drug is doing? https://www.theguardian.com/science/2017/jul/21/cancer-patie... He also drinks alcohol, he likes a pint, so perhaps he doesn't know that alcohol dissolves fat soluble vitamins from the liver, which in excess can cause a vitamin A deficiency. What he…
Comment linking /2017/02/06/glycine-and-mitochondria
on “The field of longevity biotech is a mess”Submitted Large New Survey Tracks Telomere Length and Mortality as a story · 38 points
HN discussionSlightly OT, but I was just reading some fascinating comments in [1]. The post was about cancer and mitochondria. Particularly for me, the series of comments about how the nervous system can play a role in cancer development (via inflammation promoting activity) is fascinating. There are even some comments from Carlos Monteiro, a controversial cardiologist. He postulates that cardiac glycosides (used to treat cardia…
Comment linking /2017/10/01/is-cancer-a-mitochondrial-disease/
on “Overweight and obesity are linked to cancer”Submitted Telomerase Therapies in Our Future as a story · 37 points
HN discussionInterview with the authors about the results: https://www.lifespan.io/news/diluting-blood-plasma-rejuvenat... An interesting blog post about the same paper: https://joshmitteldorf.scienceblog.com/2020/06/08/out-with-t...
Comment linking /2020/06/08/out-with-the-old-blood/
on “Diluting blood plasma rejuvenates tissue, reverses aging in mice”Submitted Fertility Is Kaput, but Life Goes On as a story · 36 points
HN discussionMy cursory understanding is that actuarial senescence (the increase in mortality rates for older populations) is not the primary driver of life span in most mammals.[1] Particularly small mammals, like lab rats. Whereas for first-world humans, it's the primary driver. Actuarial senescence makes it devilishly difficult to achieve significant life expectancy gains. Because mortality rates increase with age, life expec…
Comment linking /2012/11/10/mortality-and-life-expectancy/
on “Bodybuilding supplement promotes healthy aging and extends life span in mice”Submitted Is aging inevitable? as a story · 32 points
HN discussionA blog post about existing information about plasma exchange in humans: https://joshmitteldorf.scienceblog.com/2020/06/29/human-tria...
Comment linking /2020/06/29/human-trials-of-plasma-exchange/
on “Diluted blood plasma found to reverse aging in mice”Submitted A one-man experiment in anti-aging as a story · 27 points
HN discussionIt could be, though with a bit of Googling I found this blog post summarizing scientific studies that suggest otherwise. https://joshmitteldorf.scienceblog.com/2016/05/16/no-animal-...
Comment linking /2016/05/16/no-animal-dies-of-old-age-in-the-wild/
on “Blocking a protein curbs memory loss in old mice: study”Submitted Is cancer a mitochondrial disease? as a story · 9 points
HN discussion>And glad the research suggests it. The article is actually arguing against aging being inevitable (in the article, "My answer may be right or wrong" and below). The author also links to a blog titled "Age reduction breakthrough"~[1]. [1] https://joshmitteldorf.scienceblog.com/2020/05/11/age-reduct...
Comment linking /2020/05/11/age-reduction-breakthrough/
on “Is Aging Inevitable?”Submitted Longer proteins for longer lifespan? – Josh Mitteldorf as a story · 7 points
HN discussion> As a minor question, we see these studies a lot in mice. Are they being followed up in other animals and humans? Yeah, lots of aging studies exist. https://joshmitteldorf.scienceblog.com/2017/02/06/glycine-an... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002905/ "Glycine and N‐acetylcysteine (GlyNAC) supplementation in older adults Glycine and N‐acetylcysteine (GlyNAC) supplementation in older adults" I have ma…
Comment linking /2017/02/06/glycine-and-mitochondria/
on “Researchers Claim Serum Albumin Increases Mouse Lifespan”Submitted Mortality and Life Expectancy (2012) as a story · 7 points
HN discussionJosh Mitteldorf's nascent project using the Horvath Clock might be of interest to some people here. https://joshmitteldorf.scienceblog.com/2018/04/08/the-mother...
Comment linking /2018/04/08/the-mother-of-all-clinical-trials-part-i/
on “Study calculates effect on lifespan of healthy habits”Submitted New Aging Clock Based on Proteins in the Blood as a story · 6 points
HN discussion
